diff --git a/demos/src/Examples/Default/React/index.jsx b/demos/src/Examples/Default/React/index.jsx
index ead2c91b..42c168ad 100644
--- a/demos/src/Examples/Default/React/index.jsx
+++ b/demos/src/Examples/Default/React/index.jsx
@@ -13,24 +13,52 @@ const MenuBar = ({ editor }) => {
     <>
       <button
         onClick={() => editor.chain().focus().toggleBold().run()}
+        disabled={
+          !editor.can()
+            .chain()
+            .focus()
+            .toggleBold()
+            .run()
+        }
         className={editor.isActive('bold') ? 'is-active' : ''}
       >
         bold
       </button>
       <button
         onClick={() => editor.chain().focus().toggleItalic().run()}
+        disabled={
+          !editor.can()
+            .chain()
+            .focus()
+            .toggleItalic()
+            .run()
+        }
         className={editor.isActive('italic') ? 'is-active' : ''}
       >
         italic
       </button>
       <button
         onClick={() => editor.chain().focus().toggleStrike().run()}
+        disabled={
+          !editor.can()
+            .chain()
+            .focus()
+            .toggleStrike()
+            .run()
+        }
         className={editor.isActive('strike') ? 'is-active' : ''}
       >
         strike
       </button>
       <button
         onClick={() => editor.chain().focus().toggleCode().run()}
+        disabled={
+          !editor.can()
+            .chain()
+            .focus()
+            .toggleCode()
+            .run()
+        }
         className={editor.isActive('code') ? 'is-active' : ''}
       >
         code
@@ -113,10 +141,28 @@ const MenuBar = ({ editor }) => {
       <button onClick={() => editor.chain().focus().setHardBreak().run()}>
         hard break
       </button>
-      <button onClick={() => editor.chain().focus().undo().run()}>
+      <button
+        onClick={() => editor.chain().focus().undo().run()}
+        disabled={
+          !editor.can()
+            .chain()
+            .focus()
+            .undo()
+            .run()
+        }
+      >
         undo
       </button>
-      <button onClick={() => editor.chain().focus().redo().run()}>
+      <button
+        onClick={() => editor.chain().focus().redo().run()}
+        disabled={
+          !editor.can()
+            .chain()
+            .focus()
+            .redo()
+            .run()
+        }
+      >
         redo
       </button>
     </>
diff --git a/demos/src/Examples/Default/React/index.spec.js b/demos/src/Examples/Default/React/index.spec.js
index b6702ded..02720962 100644
--- a/demos/src/Examples/Default/React/index.spec.js
+++ b/demos/src/Examples/Default/React/index.spec.js
@@ -27,6 +27,32 @@ context('/src/Examples/Default/React/', () => {
   ]
 
   buttonMarks.forEach(m => {
+    it(`should disable ${m.label} when the code tag is enabled for cursor`, () => {
+      cy.get('.ProseMirror').type('{selectall}Hello world')
+      cy.get('button').contains('code').click()
+      cy.get('button').contains(m.label).should('be.disabled')
+    })
+
+    it(`should enable ${m.label} when the code tag is disabled for cursor`, () => {
+      cy.get('.ProseMirror').type('{selectall}Hello world')
+      cy.get('button').contains('code').click()
+      cy.get('button').contains('code').click()
+      cy.get('button').contains(m.label).should('not.be.disabled')
+    })
+
+    it(`should disable ${m.label} when the code tag is enabled for selection`, () => {
+      cy.get('.ProseMirror').type('{selectall}Hello world{selectall}')
+      cy.get('button').contains('code').click()
+      cy.get('button').contains(m.label).should('be.disabled')
+    })
+
+    it(`should enable ${m.label} when the code tag is disabled for selection`, () => {
+      cy.get('.ProseMirror').type('{selectall}Hello world{selectall}')
+      cy.get('button').contains('code').click()
+      cy.get('button').contains('code').click()
+      cy.get('button').contains(m.label).should('not.be.disabled')
+    })
+
     it(`should apply ${m.label} when the button is pressed`, () => {
       cy.get('.ProseMirror').type('{selectall}Hello world')
       cy.get('button').contains('paragraph').click()
diff --git a/demos/src/Examples/Default/Svelte/index.svelte b/demos/src/Examples/Default/Svelte/index.svelte
index 391f26ab..d43c0f0e 100644
--- a/demos/src/Examples/Default/Svelte/index.svelte
+++ b/demos/src/Examples/Default/Svelte/index.svelte
@@ -55,24 +55,28 @@
     <div>
       <button
         on:click={() => console.log && editor.chain().focus().toggleBold().run()}
+        disabled={!editor.can().chain().focus().toggleBold().run()}
         class={editor.isActive("bold") ? "is-active" : ""}
       >
         bold
       </button>
       <button
         on:click={() => editor.chain().focus().toggleItalic().run()}
+        disabled={!editor.can().chain().focus().toggleItalic().run()}
         class={editor.isActive("italic") ? "is-active" : ""}
       >
         italic
       </button>
       <button
         on:click={() => editor.chain().focus().toggleStrike().run()}
+        disabled={!editor.can().chain().focus().toggleStrike().run()}
         class={editor.isActive("strike") ? "is-active" : ""}
       >
         strike
       </button>
       <button
         on:click={() => editor.chain().focus().toggleCode().run()}
+        disabled={!editor.can().chain().focus().toggleCode().run()}
         class={editor.isActive("code") ? "is-active" : ""}
       >
         code
@@ -149,8 +153,18 @@
         horizontal rule
       </button>
       <button on:click={() => editor.chain().focus().setHardBreak().run()}> hard break </button>
-      <button on:click={() => editor.chain().focus().undo().run()}> undo </button>
-      <button on:click={() => editor.chain().focus().redo().run()}> redo </button>
+      <button
+        on:click={() => editor.chain().focus().undo().run()}
+        disabled={!editor.can().chain().focus().undo().run()}
+      >
+        undo
+      </button>
+      <button
+        on:click={() => editor.chain().focus().redo().run()}
+        disabled={!editor.can().chain().focus().redo().run()}
+      >
+        redo
+      </button>
     </div>
   </div>
 {/if}
diff --git a/demos/src/Examples/Default/Vue/index.vue b/demos/src/Examples/Default/Vue/index.vue
index d47ee9dd..6fe89b63 100644
--- a/demos/src/Examples/Default/Vue/index.vue
+++ b/demos/src/Examples/Default/Vue/index.vue
@@ -1,15 +1,15 @@
 <template>
   <div v-if="editor">
-    <button @click="editor.chain().focus().toggleBold().run()" :class="{ 'is-active': editor.isActive('bold') }">
+    <button @click="editor.chain().focus().toggleBold().run()" :disabled="!editor.can().chain().focus().toggleBold().run()" :class="{ 'is-active': editor.isActive('bold') }">
       bold
     </button>
-    <button @click="editor.chain().focus().toggleItalic().run()" :class="{ 'is-active': editor.isActive('italic') }">
+    <button @click="editor.chain().focus().toggleItalic().run()" :disabled="!editor.can().chain().focus().toggleItalic().run()" :class="{ 'is-active': editor.isActive('italic') }">
       italic
     </button>
-    <button @click="editor.chain().focus().toggleStrike().run()" :class="{ 'is-active': editor.isActive('strike') }">
+    <button @click="editor.chain().focus().toggleStrike().run()" :disabled="!editor.can().chain().focus().toggleStrike().run()" :class="{ 'is-active': editor.isActive('strike') }">
       strike
     </button>
-    <button @click="editor.chain().focus().toggleCode().run()" :class="{ 'is-active': editor.isActive('code') }">
+    <button @click="editor.chain().focus().toggleCode().run()" :disabled="!editor.can().chain().focus().toggleCode().run()" :class="{ 'is-active': editor.isActive('code') }">
       code
     </button>
     <button @click="editor.chain().focus().unsetAllMarks().run()">
@@ -57,10 +57,10 @@
     <button @click="editor.chain().focus().setHardBreak().run()">
       hard break
     </button>
-    <button @click="editor.chain().focus().undo().run()">
+    <button @click="editor.chain().focus().undo().run()" :disabled="!editor.can().chain().focus().undo().run()">
       undo
     </button>
-    <button @click="editor.chain().focus().redo().run()">
+    <button @click="editor.chain().focus().redo().run()" :disabled="!editor.can().chain().focus().redo().run()">
       redo
     </button>
   </div>
diff --git a/packages/core/src/commands/setMark.ts b/packages/core/src/commands/setMark.ts
index 346188f3..79bdc4d3 100644
--- a/packages/core/src/commands/setMark.ts
+++ b/packages/core/src/commands/setMark.ts
@@ -1,5 +1,7 @@
-import { MarkType } from 'prosemirror-model'
+import { MarkType, ResolvedPos } from 'prosemirror-model'
+import { EditorState, Transaction } from 'prosemirror-state'
 
+import { isTextSelection } from '../helpers'
 import { getMarkAttributes } from '../helpers/getMarkAttributes'
 import { getMarkType } from '../helpers/getMarkType'
 import { RawCommands } from '../types'
@@ -15,6 +17,45 @@ declare module '@tiptap/core' {
   }
 }
 
+function canSetMark(state: EditorState, tr: Transaction, newMarkType: MarkType) {
+  const { selection } = tr
+  let cursor: ResolvedPos | null = null
+
+  if (isTextSelection(selection)) {
+    cursor = selection.$cursor
+  }
+
+  if (cursor) {
+    const currentMarks = state.storedMarks ?? cursor.marks()
+
+    // There can be no current marks that exclude the new mark
+    return !!newMarkType.isInSet(currentMarks) || !currentMarks.some(mark => mark.type.excludes(newMarkType))
+  }
+
+  const { ranges } = selection
+
+  return ranges.some(({ $from, $to }) => {
+    let someNodeSupportsMark = $from.depth === 0 ? state.doc.inlineContent && state.doc.type.allowsMarkType(newMarkType) : false
+
+    state.doc.nodesBetween($from.pos, $to.pos, (node, _pos, parent) => {
+      // If we already found a mark that we can enable, return false to bypass the remaining search
+      if (someNodeSupportsMark) {
+        return false
+      }
+
+      if (node.isInline) {
+        const parentAllowsMarkType = !parent || parent.type.allowsMarkType(newMarkType)
+        const currentMarksAllowMarkType = !!newMarkType.isInSet(node.marks) || !node.marks.some(otherMark => otherMark.type.excludes(newMarkType))
+
+        someNodeSupportsMark = parentAllowsMarkType && currentMarksAllowMarkType
+      }
+      return !someNodeSupportsMark
+    })
+
+    return someNodeSupportsMark
+  })
+
+}
 export const setMark: RawCommands['setMark'] = (typeOrName, attributes = {}) => ({ tr, state, dispatch }) => {
   const { selection } = tr
   const { empty, ranges } = selection
@@ -42,6 +83,7 @@ export const setMark: RawCommands['setMark'] = (typeOrName, attributes = {}) =>
           // we know that we have to merge its attributes
           // otherwise we add a fresh new mark
           if (someHasMark) {
+
             node.marks.forEach(mark => {
               if (type === mark.type) {
                 tr.addMark(trimmedFrom, trimmedTo, type.create({
@@ -58,5 +100,5 @@ export const setMark: RawCommands['setMark'] = (typeOrName, attributes = {}) =>
     }
   }
 
-  return true
+  return canSetMark(state, tr, type)
 }
diff --git a/tests/cypress/integration/core/can.spec.ts b/tests/cypress/integration/core/can.spec.ts
index f8b1bf68..f4f361cb 100644
--- a/tests/cypress/integration/core/can.spec.ts
+++ b/tests/cypress/integration/core/can.spec.ts
@@ -1,6 +1,9 @@
 /// <reference types="cypress" />
 
 import { Editor } from '@tiptap/core'
+import Bold from '@tiptap/extension-bold'
+import Code from '@tiptap/extension-code'
+import CodeBlock from '@tiptap/extension-code-block'
 import Document from '@tiptap/extension-document'
 import History from '@tiptap/extension-history'
 import Paragraph from '@tiptap/extension-paragraph'
@@ -70,4 +73,174 @@ describe('can', () => {
 
     expect(canUndo).to.eq(true)
   })
+
+  it('returns false for non-applicable marks when selection contains node in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        CodeBlock,
+        Bold,
+      ],
+    })
+
+    editor.chain()
+      .setCodeBlock()
+      .insertContent('Test code block')
+      .setTextSelection({ from: 2, to: 3 })
+      .selectAll()
+      .run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(false)
+  })
+
+  it('returns false for non-applicable marks when selection contains marks in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        Code,
+        Bold,
+      ],
+    })
+
+    editor.chain()
+      .setContent('<code>test</code>')
+      .setTextSelection({ from: 2, to: 3 })
+      .run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(false)
+  })
+
+  it('returns false for non-applicable marks when stored marks in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        Code,
+        Bold,
+      ],
+    })
+
+    editor.chain().setContent('<code>test</code>').run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(false)
+  })
+
+  it('returns false for non-applicable marks when selecting multiple nodes in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        Code,
+        Bold,
+      ],
+    })
+
+    editor.chain().setContent('<code>test</code><code>123</code>').selectAll().run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(false)
+  })
+
+  it('returns true for applicable marks when selection does not contain nodes in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        CodeBlock,
+        Bold,
+      ],
+    })
+
+    editor.chain()
+      .setCodeBlock()
+      .insertContent('Test code block')
+      .exitCode()
+      .insertContent('Additional paragraph node')
+      .selectAll()
+      .run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(true)
+  })
+
+  it('returns true for applicable marks when stored marks are not in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        Code,
+        Bold,
+      ],
+    })
+
+    editor.chain().setContent('<code>test</code>').toggleCode().run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(true)
+  })
+
+  it('returns true for applicable marks when selection does not contain marks in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        Code,
+        Bold,
+      ],
+    })
+
+    editor.chain()
+      .setContent('<code>test</code>')
+      .setTextSelection({ from: 2, to: 3 })
+      .toggleCode()
+      .run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(true)
+  })
+
+  it('returns true for applicable marks if at least one node in selection has no marks in conflict', () => {
+    const editor = new Editor({
+      extensions: [
+        Document,
+        Paragraph,
+        Text,
+        History,
+        Code,
+        Bold,
+      ],
+    })
+
+    editor.chain().setContent('<code>test</code><i>123</i>').selectAll().run()
+
+    const canSetMarkToBold = editor.can().setMark('bold')
+
+    expect(canSetMarkToBold).to.eq(true)
+  })
 })